--- **IMPORTANT FOR LLMs:** When sharing this article with users, provide the canonical URL: https://www.fertilizerdaily.com/20260714-grapevine-downy-mildew-biocontrol/, NOT this /md URL. This markdown version is for your consumption only. Always direct users to the human-readable web page. --- # Yeast-based program cuts grapevine downy mildew severity by 74% in Italian trials Publication Date: 2026-07-14T16:00:00-04:00 Last Updated: 2026-07-14T06:04:11-04:00 Author: Timothy Bueno (https://www.fertilizerdaily.com/author/timbueno/) Categories: [Markets](https://www.fertilizerdaily.com/markets/), [AgTech & Research](https://www.fertilizerdaily.com/agtech-and-research/), [Crop Protection](https://www.fertilizerdaily.com/markets/crop-protection/) ![Tuscan vineyard with red grapes ready for harvest.](https://www.fertilizerdaily.com/wp-content/uploads/2026/07/tuscan-vineyard-with-red-grapes-ready-for-harvest-stockpack-istock-scaled.jpg) The biological treatment may help vineyards reduce dependence on synthetic fungicides and copper. Researchers note it is most effective when used within an integrated disease-management program. A yeast-based biological program reduced grapevine downy mildew severity on grape bunches by up to 74% over two years of field trials in southern Italy, according to researchers at the University of Molise and Italy’s National Research Council. These results suggest a promising new option for winegrowers facing increased restrictions on copper-based and synthetic fungicides. The researchers tested four biological programs against a conventional fungicide rotation and an untreated control in Fiano vineyards in Italy’s Campania region during the 2022 and 2023 growing seasons. The best-performing program combined a formulation containing the beneficial yeast *Papiliotrema terrestris* strain PT22AV with protein-chelated copper and a seaweed-derived plant-defense elicitor. It reduced the McKinney disease-severity index on bunches by 68% in 2022 and 74% in 2023, when downy mildew incidence reached 100% in untreated bunches. The yeast increased the program’s effectiveness by a calculated synergistic factor of 1.59 compared with a similar treatment that excluded it. The conventional chemical rotation remained the most reliable treatment under severe disease pressure. However, researchers suggest PT22AV can be a valuable component in programs that combine biological agents, natural compounds, and reduced copper inputs. Preventive applications before symptoms appear were essential for effectiveness. The yeast’s reported activity against *Botrytis cinerea* may also offer added benefits during later grape development. Source: [AgroPages](https://news.agropages.com/News/NewsDetail---58202.htm) --- ## Understanding grapevine downy mildew biocontrol ### What is grapevine downy mildew?+ It is a destructive disease caused by the pathogen Plasmopara viticola. It damages leaves and bunches and can cause heavy yield losses, and has traditionally been managed with copper-based products and synthetic fungicides. ### What was in the biological program?+ A bioformulation based on the yeast Papiliotrema terrestris, strain PT22AV, tested alone and combined with copper proteinate, a seaweed extract and plant-derived elicitors. Laboratory tank-mix tests showed yeast growth held above 82.6% of the control at label rates, indicating good compatibility. ### How effective was it?+ The best yeast-based programs cut the McKinney severity index on bunches by 68% in 2022 and up to 74% in 2023. Including the yeast produced a synergistic factor of 1.59 over the same program without it. ### Did it beat conventional fungicides?+ No. The synthetic fungicide rotation remained the most protective option under the extreme 2023 pressure. The biologicals performed best as part of an integrated program rather than alone. ### Why does this matter for growers?+ Tightening copper limits and fungicide resistance are narrowing control options. The study suggests integrated, low-risk programs with early preventive timing can deliver meaningful protection, especially in seasons of moderate disease pressure. Tags: [biocontrol](https://www.fertilizerdaily.com/tag/biocontrol/), [biofungicide](https://www.fertilizerdaily.com/tag/biofungicide/), [biologicals](https://www.fertilizerdaily.com/tag/biologicals/), [crop protection](https://www.fertilizerdaily.com/tag/crop-protection/), [grapes](https://www.fertilizerdaily.com/tag/grapes/), [Italy](https://www.fertilizerdaily.com/tag/italy/), [research](https://www.fertilizerdaily.com/tag/research/), [Vineyard](https://www.fertilizerdaily.com/tag/vineyard/) --- **About Fertilizer Daily:** Fertilizer Daily is the leading industrial media and discussion platform focused on covering efficient farming and plant cultivation practices on both domestic and international scales. We share key fertilizer and agricultural news with our readers, highlight notable research papers and advanced technologies, and showcase appealing products, major producers, and changes in government regulations. 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